in cell injury, all cells lose the ability to maintain homeostasis
plasma membrane: its the outside of the cell so its in direct contact with injury, and if this is
injured it loses ability to keep things out of the cell from toxins
function of cell will
21/ 01/ 2014
o Please make sure you have theappropriate course requirements. If youdonot, please contact Dr.
o The fibroblastscanchange properties upon receivingsignalingfrom macrophages
tobecome myofibroblasts r,vhichis
contractile.This isneeded inwound
5. Wound contraction
o Scar isnotasbig as origina
L4 Inflammation and repair part 2
Inflammation involved in many diseases.
Antibodies made already since exposed to common bacteria before, these coat
bacterium, phagocytes enter region of injury and engulf antibody coated
bacterium, mast cells rele
L5 Infectious Diseases part 1
We are surrounded by living things that are capable of causing disease.
Globally decreasing but still great.
Pneumonia causes 2nd most loss of life after heart disease. Malaria is also high.
Worse in poorer countries.
L6 Infectious diseases: part 2
-Viral infection of respiratory tract.
Selective affinity for tracheobronchial epithelial cells.
Sudden onset. More extensive than common cold.
L3 Inflammation and repair part 1
Inflammation- response of living tissue to injury
Repair- how you fix injury
No inflammation in apoptosis. Necrosis triggers inflammation.
Inflammation involved in many problems like diabetes, cancer, cardiovascular
Adaptation, injury and death of cell
Cell ADAPTATION review:
Dysplasia- give anaplasia and cancer
Eg. Prolonged exposure to cigarette smoke
makes normal ciliated epithelium go to
metaplasia and dysplasia i
L7 Diseases of the immune system
Many bacterial cells populate the body- There are 100 trillion microbial cells in
Immune system- divided into innate (quicker) and adaptive sides
Innate immunity: epithelial barriers, phagocytes, complement, Natural
April 14, 2016
Lecture #25 (April 14, 2016)
Lecture 25: Gastrointestinal Pathology: Part 3
Bile is temporarily stored in gall bladder which is stimulated to contract wh
Lecture #12 (Feb 18th, 2016)
Life style choices affect your longevity. Alcohol, Smoking, and inadequate nutrition
Problem related to inadequate nutrition
LECTURE 12 (FEBRUARY 18TH 2016)- ROBLEMS RELATED TO INADEQUATE NUTRITION
March 24 , 2016
Lecture #19 (Mar 24th, 2016)
Neoplasia: Part 1, Chapter 5
It is new growth, it is cancer.
It is hard to see in the real pictures of the tumors unless
Jan 14, 2016
Lecture #2 (Jan 14, 2014)
Cellular adaption- how cells respond to stress
All disease states involve some type of cell injury and/or cell death
Dysplasia- a st
February 9, 2016
Lecture 9 (Feb 9, 2016)
Normal aging versus disease
Chapters 1, 20, 22
Population age distribution has been radically changed in the past 15 years
CORRECTED 27 OCTOBER 2015; SEE ERRATUM
HDL-bound sphingosine 1-phosphate acts as a
biased agonist for the endothelial cell receptor
S1P1 to limit vascular inflammation
Sylvain Galvani,1 Marie Sanson,1 Victoria A. Blaho,1
CORRECTED 6 OCTOBER 2015; SEE ERRATUM
Oxidized LDLbound CD36 recruits an
Na+/K+-ATPaseLyn complex in macrophages that
Yiliang Chen,1 David J. Kennedy,2 Devi Prasadh Ramakrishnan,1,3
CORRECTED 4 MARCH 2015; SEE ERRATUM
Targeted nanoparticles containing the proresolving
peptide Ac2-26 protect against advanced
atherosclerosis in hypercholesterolemic mice
Gabrielle Fredman,1* Nazila Kamaly,2* Stefa
R ES E A RC H | R E PO R TS
RE FE RENCES AND N OT ES
1. C. S. Pittendrigh, Annu. Rev. Physiol. 55, 1754 (1993).
2. D. Bell-Pedersen et al., Nat. Rev. Genet. 6, 544556 (2005).
3. J. S. Takahashi, H. K. Hong, C. H. Ko, E. L. McDearmon,
Nat. Rev. Genet. 9, 7
Loss of Reelin protects against atherosclerosis by
reducing leukocyteendothelial cell adhesion and
lesion macrophage accumulation
Yinyuan Ding,1,2,3* Linzhang Huang,4* Xunde Xian,1,2* Ivan S. Yuhanna,4
Catherine R. Wasser
C O M M E N TA R Y
AT H E R O S C L E R O S I S
Atherosclerosis Drug Development
in Jeopardy: The Need for Predictive
Biomarkers of Treatment Response
David A. Fryburg1* and Maria T. Vassileva2*
The knowledge that a high level of low-density
Stanley Plotkin, Section Editor
Clinical Applications of DNA Vaccines: Current
Bernadette Ferraro, Matthew P. Morrow, Natalie A. Hutnick, Thomas H. Shin, Colleen E. Lucke, and David B. Weiner
Department of Pathology and L