PSYT-199A MENTAL ILLNESS AND THE BRAIN
DUE DATE: NOVEMBER 14, 2011
Read the case history and then answer the questions at the bottom of the page.
You should require no more then 2-2.5 pages in order to an
PSYT 199A Mental Illness and the Brain
Due Date: Thursday, November 28, 2011
1. Answer the question below.
2. DO NOT CONSULT any additional sources to answer the question. The
instructors would like you to use the information acquired exclusi
Theories of opiate addiction:
Person becomes physically dependent on opiates, thus they must continue use in order
to avoid fear, distress and pain of withdrawal
Opiates relieve preexisting dysphoric or
Tobacco & Nicotine; Historical Issues, Addiction
Video: Heroin addict who had a severe infection on her arm. She had talked about how she got
a strange cut of heroin which caused hallucinations her hallucination was that the
Treatment of Opioid Dependence
Instead of maintaining people on long-acting opiates for withdrawal, we are shifting towards
giving them the same drug they are addicted to but in lower doses and frequencies.
Detox: People sub
Opium poppy: Grows in dry climates. Opium comes from poppy plant, papaver somniferum
(sleep-inducing poppy). This is not the same variety as the garden plant. Opium is difficult to
synthesize in the lab; most morphine
Pharmacology and Neurobiology of Opiates
Harms of opiates are singular.
Injections of heroin are done TID-QID depending on degree of tolerance and dependence.
Users inject in a lot of veins in the body, e.g. neck veins, wrist
Health Burden, Epidemiology and Historical Issues
Health burden can come from drug abuse and dependence, trauma related to alcohol (very
costly to society, and a prominent source of mortality), organ damage related to alcohol
Neurobiology and Genetics of Alcohol Dependence
All drugs of abuse increase dopamine in the brain, especially amphetamine (microdialysis).
The mesocorticolimbic DA neurons form a crucial drug-sensitive component of rewardrela
Sedative and Hypnotic Wrap-up
There is a strong heritability component of alcohol and drug dependence. Factors in
development of SUD: Physiology (e.g. alcohol metabolism, craving, reward, etc.), genetics,
behaviour (e.g. pers
Lecture 4 Alcohol contd; Absorption, Intoxication
Route of administration changes peak effect, bioavailability, rate of onset
Alcohol routes of administration:
AWOL (alcohol without liquid): Allows alcohol mist to be inhaled this all
Case of Mr. F: Withdrawal, physically dependent, self-medicating with Ativan to mask effects
of withdrawal, social/family activities affected, tried to reduce intake, continued use despite
negative consequences (criteria of substance abuse).
Signs: things you can observe
Symptoms: things you can report
Signs and symptoms differ between disorders
Comorbidity high in those with substance use disorders
Only do 8% better on test compare
Issues in Drug Dependence Psyt 301B
Kathryn Gill Ph.D. Associate Professor, Psychiatry Department
Director of Research, Addictions Unit, McGill University Health Centre
why this course? course description and organization textbook key concepts outline o
Lecture 3 Case Presentation & Introduction to Alcohol
KEY CONCEPTS DSM-IV diagnostic criteria methods of screening for alcohol/drug abuse historical issues A Nation of Drunkards alcohol as a commodity (rum, slave trade) Intemperance Temperance Prohibition
Lecture 6- More on GABA + Genetics of Alcoholism
KEY CONCEPTS GABAA and alcohol-related behaviour (animal studies) twin and adoptee studies of alcoholism COGA collaborative study on the genetics of alcoholism in the US potential genetic markers and candid
Lecture 8 Wrap-UP Sedative Hypnotics
The Problem Was(Moyers film clip) Case Presentation 2
be able to answer the questions raised by this case presentation.
Film Clip The Mind Brain Mechanisms of Pleasure and Addiction (this clip is