AN IMMUNOBIOLOGY TEACHING PACKAGE
Originally Developed by:
1999 Revision by:
Parker A. Small, Jr., M.D.
Eric Brestel, MD
Dept. of Immunology & Medical Microbiology
University of Florida College of Medicine
LEARNING OBJECTIVES for THE MAJOR HISTOCOMPATIBILITY COMPLEX:
STRUCTURE AND FUNCTION (STOUT) by Justin Morgan
1. The student will be able to describe the Major Histocompatibility Gene Complex
and its 3 major components: Class I, Class II and Class III.
LEARNING OBJECTIVES for Lymphocyte Development and Differentiation (Stout)
by Justin Morgan
1. The student will be able to explain the developmental distinction between ( and
T cell lineages.
2. The student will be able to describe, in general terms
LEARNING OBJECTIVES : Cells and Tissues of the Immune System
The Innate Immune System
1. The student will be able to identify the different cell types in the peripheral blood and their
o Most prominent in acute inflammation
1LEARNING OBJECTIVES OVERVIEW OF THE IMMUNE SYSTEM by Justin Morgan
The student will understand the relationship of innate and acquired immunity.
The key weapons of the more primitive innate system are phagocytes and complement.
The key weapons of the
LEARNING OBJECTIVES for Antigens and Antibodies (U.N. Streips) by Justin Morgan
You should be able to define what immunoglobulin molecules are:
Immunoglobulins are glycoproteins made up of light (L) and heavy (H) polypeptide chains. They
are the antige
Learning Objectives: Genetic Basis for Antibody and T Cell Receptor Diversity
1. Understand the genetic arrangement of the light and heavy chains of the immunoglobulins. Know the role
of V, D and J regions
A. Genetic Arrangement of the Light and Heavy Cha
Explain the relationship of innate and acquired immunity.
Innate, or non-specific, immunity consists of anatomical barriers like skin
and mucous membranes as well as physiological barriers like temperature, pH,
Lymphocyte Development and Differentiation
I. Explain the developmental distinction between and T cell lineages.
A. Both and T cells come from a common progenitor
1. Called thymoblasts
2. Are double negative (CD4-, CD8-)
3. Do not express CD3 or TCR (T-
B Cell Activation: The Antibody Response
Describe the progressive stages of the primary antibody response.
1. Lag Phase
2. Appearance of IgM (then sometimes followed by IgG or another class)
During the lag phase, pathogens and antig