The present study examined the hearts of fiddler crabs to determine the
physiological effects of exposure to varying concentrations of a common pesticide. The
pesticides active ingredient, cypermethrin, has been shown to disrupt animal neuronal
Under sterile conditions, the heart of 139 adult male and female shore crabs, Carcinus
maenas, were used in order to explore the integral membrane properties and hormonal
responses of individual neurons in the cardiac ganglion. To begin, the cardiac gangl
Prion (PrP) (transmissible spongiform encephalopathies (TSEs):
Stanley B. Prusiner won the nobel prize for his discovery of prions in 1997. He started
researching prions after one of his patients died from CJD.
A prion is an infectious agent made up of pr
NEUROBIOLOGY - BI274
Syllabus - Fall 2012
Instructor: Andrea Tilden
Olin 334, [email protected], 859-5743
Course Description: BI274 is a CELLULAR-LEVEL NEUROSCIENCE COURSE.
Neurobiology is a rapidly expanding and exciting area of biology. Neuroscience is
Now were going to look at neuromodulators
Give me 1 to 12 examples really quickly. Acetyl choline, gabba A receptor, Gabba B
Neurotransmission is very simply a change in membrane potential (permeability) in
response to NT binding.
Review from pervious week of length constant, the distant at which it reaches 37% initial
amplitude, measured in micrometers. If its a constant why does it have units? The actual
constant is calculated with units that all cancel out.
Things that wil
Synaptic integration is the way that electrical signals, once theyve gotten into the post
synaptic cell, EPSP & IPSP. Look at the way that they interact with each other and make
it to the spike initiation zones. Weve started at the beginning of the
Sodium/K depolarization in the post synaptic cell is where we start.
We talked about the Ach synapse where Ach is released and nicotinic acetyl choline is the
receptor. It causes Na+ to go into the cell and K+ out of its cell down its concentration
Two examples of G protein systems: Adenylyl cyclase system and Phospholipase C
When the NT binds to receptor, the receptor activates the G protein. When activated, the
alpha subunit separates and becomes active and goes and activates another
We left off last time with the cardiac pacemaker system. It is interesting because it is self
perpetuation in the nervous system. It sets a rate and continues on and on. There are these
channels (HCN sodium channels) that open in response to hyperpol