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Chemical Principles 8th Edition

Chemical Principles (8th Edition)

Book Edition8th Edition
Author(s)DeCoste, Zumdahl
ISBN9781305581982
PublisherCengage Learning
SubjectChemistry
Section 21.6: Natural Polymers
Critical Thinking
End of Chapter
Chapter 21, Section 21.6, Critical Thinking, Exercise 01
Page 877

What if you contracted a disease that prevents all hydrogen bonding in proteins? Could you live with such a condition?



Explanation

bio.libretexts.org/Bookshelves/Biochemistry/Book%3A_Biochemistry_Free_and_Easy_(Ahern_and_Rajagopal)


ncbi.nlm.nih.gov/books/NBK470235/

Answer

-If you contracted a disease that prevents all hydrogen bonding in proteins then you can not live with such a condition.

-This is because hydrogen bonding is involved in the secondary, tertiary, and quaternary structure of protein which makes a protein functional.

-The polypeptide backbone forms a repeating helical structure that is stabilized by hydrogen bonds between a carbonyl oxygen and an amine hydrogen.

-These hydrogen bonds occur at regular intervals of one hydrogen bond every fourth amino acid and cause the polypeptide backbone to form a helix.

-In the β-pleated sheet, the "pleats" are formed by hydrogen bonding between atoms on the backbone of the polypeptide chain.

-Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.

-The correct three-dimensional structure is essential to function.

-Folding is a spontaneous process that is mainly guided by hydrogen bonding.

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