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W Feeua eeneepta: The three dinienaiunal enueture elfireeulht is examined and Mqumees Inf Vl'i'll animal insulina are aampared. Background Diabetics...

Q18. Using the data in Table 2, explain why the immune system would be able to distinguish animal insulin from human insulin. 

Q20. Why is insulin unable to re-create the disulphide bonds correctly after denaturing? 

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Screen Shot 2018-03-30 at 7.28.53 PM.png

W Feeua eeneepta: The three dinienaiunal enueture
elfireeulht is examined and Mqumees Inf Vfll'ifl'llfi
animal insulina are aampared. Background
Diabetics laek theprntain insulin, 1III.I']:IiII::h is Ptfldllmd by the paltereafie El-eella nt'the islets of
Langerhans. Insulin elirnulatea uptake efglueuee
film: the bland inta the tissnm Diahema is
t'i'vlaailltal'lhr}.r raplaaing the missing insulin. thnan
imam is [Induced industrially by reamnhinant
bacteria, but hefiare this Inefllud was available.
animal maulill was used mataad. insulin eunsisla elftwu pnly'pepfide chains, an
a ehain and a B ehainl jeinerl together by
diaulfide hands. The smaller-1' efthe two ahainsia
rafan'uflta as thafl ahailtandisfll amine aeida
lung inhumane. 'l'heaeeend ehainiereferredte
aethe Behainanflis 3U aminnaaids lungin
m" Pram“ ‘5 Wad "1 “’3 Figure 2: Structure nf pre-insulin. “‘1"le Emma elm it is EMF-d and '1“ {From treat and Veal, 1aa5, p. 193.}
disulfide bonds are DIldlIEd. It 1s than transported tn the Gnlgi apparatna where it ie packaged inte eemetm-jr veeielee, and where it
ie prueeeaefl by a eeriee ufpruteaeee to farm mature insulin. Manna ineuhn has 33 fewer
amine aeide; foaming the C-pePfifle. The C-peptide ie ahetraetefl from the middle ef the
prninsulin aequeuee;the twu ulherenfie [theB ehain andi-tehainherrein eenneeleahy
diaulfide henna Insulin frnm valiuus animals is similar tn, but not idemieal tel human insulin, as
illustrated in Table l a aeheruatie diagram of the euuetuie of insulin ie shown in Figure 1. Table I: Variatieln inpnsifinns A8, A9, All], El , '32, BE"? and E30 nfinsulin. {All
other amino aeic'le are the same.)

Top Answer

19.In all the animal insulins there is a slight amino acid differences in one ,two or more than two pints which causes immune... View the full answer

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18) Human and animal protein differs in amino acid residues which results in the different structure of protein in both... View the full answer

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