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Because many clotting factors are present in blood in small concentrations, direct chemical measurements often

cannot be used to determine whether the factors are within normal concentration ranges or are deficient. Once a deficiency has been established, however, plasma from the affected person can be used to screen for the presence of the deficiency in other people. A rare deficiency in Factor XII leads to a prolongation of clotting time. Assuming that you have plasma from someone in which this deficiency has been established, design a test that might help determine whether another person has a Factor XII deficiency.

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initially, routine blood coagulation test is done. if the sample is taking more than expected time to coagulate,... View the full answer

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