A previously unknown odd metabolic disease was isolated in a patient. Upon further research, scientists noticed
that this disease was a result of a specific mutation in one of the key enzymes involved in the glycolysis pathways. It was discovered that at position 112, Aspartate had been mutated to Valine resulting in the aggregation of the protein. Which one of the following replacements at position 112, would have been least detrimental to the shape of the protein?
*Follow Up question: How does a mutation such as the above, affect the shape of the mutated protein?