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In high throughput screening, the key is the accuracy of the assay. When NIH or FDA evaluates a
drug discovery program, they require the applicants to report the accuracy of the screen. If you
are leading the project of a pharmaceutical company to test a million compounds to identify the
inhibitors of your dream target, the success of the project will be highly dependent on the false positive and false negative rate of the assay. If your assay has a false positive rate of 2% and a false negative rate of 1%, when you identify a
hit (meaning positive result), What is the chance this result is true (assuming in reality about 1%
compounds are real inhibitors). Please describe very briefly how you arrived at the answer.

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