PS.. use different sources and cite them properly. Use in-text...

PS.. use different sources and cite them properly. Use in-text citation and collate all the references at the end.

 

• What are the three major pathways that eventually become entry points of molecules into the Krebs Cycle? Which molecules from these respective pathways are integrated into the Krebs Cycle? 
• How is a "committed step" defined in the context of a metabolic pathway and why are they important? Which steps and/or enzymes are involved in the committed steps in the Krebs Cycle? What are the possible implications of these steps being deregulated? 
• What are the three Krebs Cycle inborn errors mentioned in the paper? Why are they called deficiencies? What do you think are the probable causes for these? 
• In your words, what do you think is/are the reason/s why most of the clinical features of these diseases involve muscle and nerve tissue? 
• Given the clinical manifestations, what suggestion do you have pertaining to the management of the diseases mentioned?