View the step-by-step solution to:

Design a fabrication process for a device capable of closed-loop control of glucose, pH, and lactate from a cell culture petri dish. The device...

Design a fabrication process for a device capable of closed-loop control of glucose, pH, and lactate from a cell culture petri dish. The device should be able to:

  • Extract a small volume of the solution from the dish.
  • Perform the pH, glucose and lactate sensing on the extracted solution utilizing a parallel process.
  • Deliver the required amount of compound to maintain a steady concentration of each analyte.
  • Perform intracellular sensing of glucose, pH, and lactate from a selected cell in the petri dish.

Your answer should consist of:

1- Present your approach and the reasoning behind your design in one page.

2- Draw the overall cross section of the system, labeling each part and its approximate dimension both in terms of thickness and lateral size.

a) Describe each section's working mechanics; see below for some examples that can be incorporated into your design if applicable.

- Glucose sensing is performed with a transistor, based on enzymatic reaction process. This process involves immobilization of the glucose oxidase enzyme at the transistor gate.

- Solution is drawn into 3 separate chambers using high surface energy contrast paths generated by a self-assembly monolayer (SAM) that creates a hydrophobic/hydrophilic surface.

- Protons are delivered to the dish using an electrochemical ion pump made from conducting polymers

b) Describe your choice of material for each layer and its critical properties.

3- Draw the step-by-step fabrication process of the device, including the method of process, the reasoning behind your choice, and the characterization method for the process.

Recently Asked Questions

Why Join Course Hero?

Course Hero has all the homework and study help you need to succeed! We’ve got course-specific notes, study guides, and practice tests along with expert tutors.

-

Educational Resources
  • -

    Study Documents

    Find the best study resources around, tagged to your specific courses. Share your own to gain free Course Hero access.

    Browse Documents
  • -

    Question & Answers

    Get one-on-one homework help from our expert tutors—available online 24/7. Ask your own questions or browse existing Q&A threads. Satisfaction guaranteed!

    Ask a Question