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Thanks so much. Travelling in Maldives, Indiana Jones lost his boot stepping into a muddy river.

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1. Travelling in Maldives, Indiana Jones lost his boot stepping into a muddy river.

Unfortunately, a parasitic worm drilled through the tough skin of his foot, invading

his bloodstream. How would his immune system recognize the parasitic worm?

Which cells would be most likely to be used to expel the worm from his system?

What would be released from these cells to aid in the expulsion of the worm?

2. Describe how Mudd et al. attempted to mimic an alternative portion of the

immune system to make a CD8+ type of response towards vaccinating against

HIV. What contrasts with their approach when compared to the traditional

mechanism used in vaccination development?

3. Judy is pregnant with her second child from her husband Jim. Judy has AB-

blood while Jim has O+ blood, their first child has B+ blood. Given this

information, what type of blood could the fetus have? From an immunologic

perspective, how would the blood type of the first child change the body's

response to the second child? What would be the clinical outcome of giving no

treatment to Judy and how can this be avoided?

4. Prince Charming is severely allergic to cats and dogs. His one true love,

Cinderella, unfortunately loves all creatures small to large and keeps them

around her hut in the middle of the woods. Using the ideas of prevention,

pharmacological intervention and desensitization, describe how Prince Charming

could prepare himself for living with Cinderella and the woodland creatures.

5. Westley knows that his future endeavors rely upon building a tolerance to

iocaine powder - a powder that induces inflammation similar to a Type III

hypersensivity. Describe how Westley could develop a tolerance to the

poisonous powder through desensitization or other mechanisms.

6. Compare and contrast hyper-acute transplant rejection and graft vs. host

disease. Be sure to include the mechanism behind the rejection and potential

mechanisms for avoiding each case.

7. The only case of full recovery from HIV is a unique one of a patient who

received a full blood donation that happened to have a mutated CCR5

(CCR5∆32). Why did this specific mutation "cure" the patient of HIV? Be specific

in your response to describe what would happen with a fully functional CCR5

gene.

8. Measles is once again spreading across a variety of communities in the

broader United States. What might an editorial to a local paper that describes the

following: A) How a vaccine works from an immunological perspective, B) Why it

is important to vaccinate children from the point of view of herd immunity and C)

Why some diseases cannot be vaccinated against.

9. How does complement allow for the destruction of a variety of pathogens?


Make sure to include a description how of the major mechanism of activation for

each branch of the complement cascade plays a role in this response. A diagram

would be useful.

10. Describe how the mechanisms for fighting disease in the GALT differs from

the response that is found in other parts of the body.

11. HIV attacks CD4+ t-cells. Describe how the virus enters these cells and what

the long-term repercussions of this attack are.

12. Compare and contrast the development of the BCR and the TCR.

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