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The mechanism of valproate action is:

. The mechanism of valproate action is:

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a) Facilitation glutamic acid decarboxylase, the enzyme responsible for GABA synthesis and inhibition of GABA-

aminotransferase, the enzyme responsible for the breakdown of GABA (enhance GABA accumulation)

b) Inhibition of voltage sensitive Na+ channels

c) Inhibition of low threshold (T-type) Ca2+ channels

d) All of the above

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option D. All of the above. it enhances GABA mediated neurottansmission,... View the full answer

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