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In the quest to understand the basis of infertility in humans,...

In the quest to understand the basis of infertility in humans, researchers have identified a mutation in a gene associated with chiasmata. This protein normally acts to promote homologous recombination. 

Why might a defect in homologous recombination have consequences for fertility? 

  •  A. The chiasma checkpoint halts the whole process of meiosis if crossovers do not form properly.
  •  B. Crossover formation is a necessary step in meiosis I to ensure proper chromosome segregation.
  •  C. A checkpoint requires a certain level of genetic variability for meiosis to proceed.
  •  D. Chiasmata are the connections between the centromeres and the centrosomes that pull them to each pole of the daughter cells.

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