Below is a graph showing the dose response curve for an endogenous ligand (Y) at its receptor. a) Drug Z has a 100x higher affinity than Y, but the
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This question is from NPB 168 (Drug Addiction) class. Screen Shot</h1><p class='abPRemoveTitle'> 2019-10-02 at 10.31.38 AM.png

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Below is a graph showing the dose response curve for an endogenous ligand (Y) at its receptor.
a) Drug Z has a 100x higher affinity than Y, but the same efficacy. Draw what the dose response
curve should look like (compared to endogenous ligand already on the graph). Label it &quot;Z&quot;
b) Drug A has 100x lower potency but higher efficacy than Y. Draw what the dose response curve
should look like. Label it &quot;A&quot; What property of A could account for its low potency?
c) Drug B has lower efficacy but higher 1000x higher affinity than Y. Draw what the dose
response curve should look like. Label it &quot;B&quot;
Response
N W
Y
O
-9
-8 -7 -6 . -5
-4
log dose (nM)

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