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Below in Figure 1 is a pedigree for a family afflicted by a genetic

disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency.  However this disease may not have the same type of genetic transmission as cystic fibrosis.
a.     What type of genetic transmission is most consistent with the pedigree? 
b.     Label all the individuals that you can determine, with hypothesized genotypes. 
c.      Label the individuals that have unknown genotypes with possible genotypes.
d.     Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease.
e.     Use the Χ2 test to determine whether your proposed transmission fits this data.

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Subject: Biology, Science

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