a) necrosis is unregulated cell death and hence is wasteful of cellular components, while apoptosis is highly regulated and allows for recycling of cellular structures.
b) necrosis is cell death but apoptosis causes cell growth
c) necrosis requires activation of MAP kinase but apoptosis does not
d) necrosis is mediated by a series of protein phosphorylation step while apoptosis is mediated b y a series of protease activation steps
e) necrosis happens slower than apoptosis but otherwise they are identical
Select the proper temporal sequence of signaling events associated with growth factor binding to the cell surface.
i. Autotransphosphorylation of receptor
ii. Phosphorylation of MAP kinase
iii. Binding of Grb2 to SOS
iv. Dimerization of receptor
v. Exchange of GDP for GTP
a. i, iv, iii, ii, v
b. iv, i, iii, v, ii
c. i, iv, iii, v, ii
d. iv, i, iii, ii, v
e. iv, iii, i, ii, v
11. Which of the following is the most accurate description of the mechanism of apoptosis?
a. A cell receives external signals that initiate a cascade of protease activation events in the cytosol; the activated proteases digest the cell from the inside-out, so that none of the cellular proteins leaks into the extracellular space.
b. A cell receives external signal that stimulate the neighboring cells to engulf it, the cellular contents are eventually digested in the lysosome soothe neighboring cells
c. A c cell receives external signals that cause the cell to secrete proteases that digests the surrounding extracellular matrix; the loss of contact with ECM causes the plasma membrane to rupture and the cell “bleeds to death”
d. Apoptosis is also known as “programmed cell death” and thus it is driven by a signal that originates in the nucleus; the signal is transmitted to the cytosol where it is converted into protease proteins that digest the cell from the inside out
e. None of the above is more accurate than the others.
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