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Activation of T cells requires that antigens be presented from antigen-presenting cells, not simply by exposure to the antigen in solution.

Activation of T cells requires that antigens be presented from antigen-presenting cells, not simply by exposure to the antigen in solution. What biological rationale may underlie this requirement – consider both from the perspective of how this can aid in the generation of a cytotoxic T cell response, and how it may aid in avoiding undesirable T cell responses.

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