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Probe Z is 4.0 kb in length.

Probe Z is 4.0 kb in length. Use diagrams to explain how each of the following RFLP polymorphisms might be obtained with probe Z and appropriate restriction endonucleases with six nucleotide recognition sites.

a. a haplotype consisting of a single fragment 5.7 kb in length vs. a haplotype consiting of fragments 3.0 and 2.7 kb in length.
b. a single fragment 4.2 kb in length vs. a fragment 7.3 kb in length.

c. A haplotype consisting of fragments 4.7 and 5.1 kb in length vs a haplotype consisting of fragments 2.5 and 4.7 kb in length.

d. A haplotype consisting of fragments 2.5, 4.7 and 5.1 kb in length vs. a haplotype consisting of fragments 3.6 and 5.1 kb in length. (Hint: think in terms of sampling the general population and do not assume that the difference necessarily arises from a single mutational event.)

e. What general pattern of fragments would you expect to see if you used the same probe with a restriction endonuclease that has a four nucleotide recognition site.

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