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Question 1 1 points Save During which stage of the cell cycle is the chromosome content of a mammalian liver cell 1n?

Question 1 1 points Save
During which stage of the cell cycle is the chromosome content of a mammalian liver cell 1n?
G1
S
G2
none of the above



Question 2 1 points Save
Human genes/proteins that regulate the cell cycle are most easily isolated by
biochemical purification.
complementation of Xenopus mutants.
complementation of yeast mutants.
positional cloning.



Question 3 1 points Save
Injection of an immature Xenopus oocyte with MPF induces
meiosis.
oocyte maturation.
synthesis of progesterone.
a and b



Question 4 1 points Save
All the following statement(s) about destruction of cyclins is (are) true except
Destruction is carried out by proteasomes
Destruction is preceded by polyubiquitination
Ubiquitination occurs at specific sites on target molecules
Ubiquitin targets Cdks



Question 5 1 points Save
Mitotic cyclin levels in early Xenopus embryos are regulated by
phosphorylation.
synthesis and degredation of their mRNAs.
degradation by APC.
degradation by MPF.



Question 6 1 points Save
Which of the following is a target of the APC?
Cdc25
cyclin B
separase
a and b



Question 7 1 points Save
Site-directed mutagenesis of Tyr-15 to Phe in cdc2
results in the wee phenotype.
results in a phenotype similar to that caused by mutation in cdc25.
increases the possible number of phosphate groups on Cdc2.
prevents binding of Cdc13.



Question 8 1 points Save
Which of the following S. pombe mutants is larger than normal?
cdc2D
cdc25-
wee1-
b and c



Question 9 1 points Save
Exit from mitosis depends upon the degradation of
cohesion.
condensin.
cyclin B.
securin.



Question 10 1 points Save
The S. cerevisiae homolog of Xenopus MPF is
Cdc13-Cdc2.
Cdc25-Cdc2.
Clb1-Cdc28.
Cln3-Cdc28.



Question 11 1 points Save
Which of the following is a substrate of Cln3-Cdc28?
SBF
SPF
MPF
a and c



Question 12 1 points Save
Which of the following is targeted by the SCF?
Cdh1
cyclin B
securin
Sic1



Question 13 1 points Save
During G1, prereplication complexes
are phosphorylated by B-type cyclin-CDKs.
are phosphorylated by DDK.
bind to ORC.
all of the above



Question 14 1 points Save
Cyclin D/Cdk4 functions during
G1.
S.
G2.
M.



Question 15 1 points Save
Which of the following inhibits cyclin A/Cdk2 activity?
INK4
p21CIP
Rb
a and c



Question 16 1 points Save
Failure of which cell-cycle checkpoint is most likely to result in nondysjunction?
chromosome-segregation checkpoint
DNA-damage checkpoint
unreplicated DNA checkpoint
a and b



Question 17 1 points Save
Chk1is activated by
ATR.
Mad1.
p53.
b and c





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