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1. Many of the larger DNA viruses are able to enhance viral protein translation by coding for ribosomes that selectively translate viral proteins.

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1. Many of the larger DNA viruses are able to enhance viral protein translation by coding for ribosomes that selectively translate viral proteins. True False 2. A viral messenger RNA has the following sequence: AUG AGU GGG GCC CAU GGG AAA CCC AGG UUU The following proteins are produced: MetAsnGlyAlaHisGlyLysProArgPhe MetGlyAsnProGly What is the mechanism that generates this diversity? A. Polyprotein Synthesis B. Ribosomal frameshift C. Leaky Scanning D. Suppression of Termination 3. A viral messenger RNA has the following seq AUG AGU GGG GCC CAU GGG AAA CCC AGG The following proteins are produced MetAsnGlyAlaHisGlyLysProArgPhe… MetAsnGlyAlaProTrpGluThrGlnVal… What is the mechanism of diversity viral mRNA? A.Reinitiation B. Suppression of Termination C. Leaky Scanning D.Ribosomal Frameshift Fill in the Blank. 5. The genomes of (+) RNA viruses can be translated immediately upon cellular entry, even though they do not possess a 5' 7-methylguanosine cap due to the presence of this structure at the 5' end of the genome [x]. 6. Most viral infections induce activation of the eIF2a kinase PKR which halts protein translation in an infected cell. Which of the following mechanims enable viruses to evade the antiviral effects of PKR (Select all that apply)? A . Viral protein binds to PKR dsRNA binding site and activates PKR autophosphorylation. B. Viral protein inhibits eIF2a phosphatase.
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C. Viral proteins inhibit dsRNA binding to PKR D . Viral proteins act as pseudo-substrates that inhibit PKR kinase activity E. Virus produces its own kinase that phsophorylates eIF2a. 7. Describe how picornaviruses are able to produce multiple proteins from a single mRNA (Limit 3-5 sentences). 8. The figure below depict an SDS-PAGE protein gel in which total cell protein is visualized at various time points after a viral infection. The protein bands labled 1A, 2 and VP3 are all viral proteins. Explain in 2-4 sentences what is occurring in this figure and why it is advantageous to the virus.
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1. Many of the larger DNA viruses are able to enhance viral protein translation by coding for
ribosomes that selectively translate viral proteins.
True False 2. A viral messenger RNA has the...

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