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What is the main goal for this lab and how do i outline a plan to experimentally collect data for

mbasevs. VCO2plot that can be applied to the knowns (pure NaHCO3or CaCO3). In other words, prepare a procedure to measure the volume of gas (VCO2) evolved with different masses of base (mNaHCO3ormCaCO3) reacting with fixed amounts of HCl that can be used to establish the behavior of NaHCO3or CaCO3.

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Chemical Thinking
Project 8
v1.3 1
Reaction Control 1: Determining the Neutralizing Capacity of Antacids
Project 8
Antacids are commonly used for relieving upset stomach and heartburn (acid reflux). They also find
use in alleviating the pain of gastric (stomach) and duodenal (small intestine just after the stomach)
ulcers. Examples of over-the-counter (OTC) antacids include Rolaids, Tums and Maalox. Despite
the many commercial brands, the active ingredient of virtually all antacids are simple inorganic
weak bases that work by neutralizing excess stomach acid, which is primarily hydrochloric acid, HCI.
In this research project, you will explore and learn how to characterize and control an acid-base
system that generates a gas product. By relating the volume of gas evolved to different amounts of
base reacted with fixed amounts of acid, the limiting reagent concept is illustrated, and the amount
of base required to neutralize a fixed amount of acid can be determined.
P8-1 Background
Graph 8.1 Volume of CO, Evolved from Reaction of
Different Antacid Masses with 10 ml of 0.30 M HCI
The most common bases employed in antacids are carbonates or bicarbonates such as sodium bicarbonate
(NaHCO3) and calcium carbonate (CaCO3). The reactions by which these antacids neutralize gastric acid
(HCI) can be represented as:
CaCO3/s] + 2 HCI(2q) > CaClz(=q) + Hzog + COZ(E)
NaHCO3(s) + HCl(aq) -> NaCl(ag] + Hzog) + CO2()
In this research project, different antacid brands will be analyzed to determine the moles of HCI
Volume of C
neutralized per gram of antacid (molHo/mantacid) and thus characterize the acid neutralizing capacity of the
antacid. The analytical methodology will capitalize on the carbon dioxide gas (COz) generated in the
neutralization. In this procedure, a known volume of HCI (Vio) of known molar concentration (Myo) is
Mass of Antacid ()
reacted with a weighed portion of a ground antacid tablet which contains either NaHCO3(s) or CaCO3/s) as
the active ingredient. From the above balanced chemical reactions, reaction of either NaHCO3:) or CaCO3(s) with HCI results in the evolution of CO2;). By collecting and
measuring the volume of gas evolved, the amount of COz) produced by a given mass of antacid reacting with a given amount of HCI can be determined. Conducting the
experiment with different masses of antacid (Mantacid), but the same amount of HCI (fixed volume of HCI at the same molar concentration), a plot of antacid mass versus
volume of COZ(E) (mantacid VS. Vcoz) can be prepared for each antacid (Graph 8.1). Note that each plotted point in Graph 8.1 represents an individual trial; hence,
constructing the Mantacid VS. Vcoz plot presented as Graph 8.1 required 14 separate runs. Analysis of a mantand vs. Vcoz plot will reveal the minimal antacid mass for which all
the HCI has been neutralized. From this, the molio neutralized per gram of antacid (Mantood) may be inferred and thus affords a means to compare the acid neutralizing
capacity of one antacid against another. Controls will be important in the analysis. Pure NaHCO: and CaCO3, which are solids, should be run. Such experimental controls
are often called knowns (the antacids are then, the unknowns). Comparison of the NaHCOs and CaCOs mboss VS. Vcoz results against those of the antacids should reveal
which weak base each antacid contains, and the presence of inert components such as binders and fillers in the antacid tablet formulation.

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