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This question was created from Chapter 4


An 18 base-pair deletion in the PAX-3 gene causes Waardenburg
syndrome (an autosomal dominant disease that is responsible for a
small percentage of deafness cases in humans). Of the many molecular
approaches available to distinguish between the mutant allele and
"normal" allele of this gene, what approach would work in this case?
1.PCR amplification of each allele then
determine PCR product size
2.RFLP analysis
3.DNA sequencing
4. Hybridization to detect CAG repeats
5.None of the above

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