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14.Although it is always a severe disease, the severity of sickle cell disease is determined partially by
the haplotype on which the mutation occurs. How could the haplotype affect disease severity?
Describe penetrance and how this affects disease severity using another congenital genomic
disorder as an example. Sickle cell provides an example of heterozygote survival advantage. What
is this and what other disorders can you think of that express this same advantage? What is the
rationale for hvnofhesi7inn a hefer07vaofe advantage for those diseases?

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