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Hyperaldosteronism (excessive aldosterone release) can be caused by many disease states including tumours in the adrenal gland.

Hyperaldosteronism (excessive aldosterone release) can be caused by many disease states including tumours in the adrenal gland. By now, we should be familiar with how this will affect sodium balance and blood pressure, but how would hyperaldosteronism affect potassium levels and why? Select one potassium effect (a or b) and one cause (c-f).


The patient will become hyperkalemic


The patient will become hypokalemic


Aldosterone increases sodium reabsorption in the proximal tubule. Increased sodium reabsorption increases water reabsorption, which then establishes a concentration gradient to increase potassium reabsorption.


Aldosterone increases sodium reabsorption in the collecting duct. Increased sodium reabsorption increases water reabsorption, which then establishes a concentration gradient to increase potassium reabsorption.


Aldosterone increases sodium reabsorption in the collecting duct by increasing expression of EnaCs, sodium/potassium exchangers, and sodium/hydrogen exchangers on the luminal membrane. Thus as sodium reabsorption increases, potassium secretion increases.


An increase in sodium reabsorption reduces activity of the sodium/potassium pump. This increases ECF potassium concentrations, increasing potassium clearance.

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    • gambani
    • May 14, 2018 at 8:48am

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The correct choice for potassium effect is b. The patient will become hypokalemic The... View the full answer

Hyperaldosteronism (excessive aldosterone release) can be caused by many disease states including tumours in the adrenal... View the full answer

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