Two different sodium glucose transporters (SGLT1 and SGLT2) have a Kd for glucose of 0.3 mM and 6 mM,
respectively. Which is the low-affinity transporter and which is the high-affinity transporter? Using glucose concentrations of 0.1, 0.3, 0.6, 1, 3, 6, 10, 30, 60, and 100 mM, plot the fraction of bound transporters of each type. Plot concentration on the horizontal and % bound transporter on the vertical axis. From the plots, estimate at what concentration 50 % of the transporters are bound and at what concentration are ~95 % of the transporters are bound? Can you calculate the concentrations at which 95 % of each type of transporter is bound to glucose?
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