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# In a cohort study with no loss to follow-up, disease status was misclassified as follows: Study Population without Misclassification I11 Healthy...

1.State which of the following studies is more precise—that is, which has a smaller amount of random error:

Study A with a RR of 1.07, 95% CI 0.9-1.8, or Study B with RR of 1.45, 95% CI 0.8-2.5

1. In a cohort study with no loss of follow up, disease status was misclassified as follows:

study Population without Misclassification

a. What is the most appropriate relative measure of association to use in this study?

b. Comparing the study population with and without misclassification using this measure of association, is there evidence of information bias? It is not sufficient to just say yes or no. Provide a written sentence justifying your answer, and show the calculations you use to develop your answer.

c. If there is evidence of information bias, is it differential or non-differential? Explain why by comparing the errors in misclassification of disease between the exposed and unexposed.

d. If there is information bias, is it towards or away from the null? Why?

a. What is the most appropriate relative measure of association to use in this study?

b. Comparing the study population with and without misclassification using this measure of association, is there evidence of information bias? It is not sufficient to just say yes or no. Provide a written sentence justifying your answer, and show the calculations you use to develop your answer.

c. If there is evidence of information bias, is it differential or non-differential? Explain why by comparing the errors in misclassification of exposure between the cases and controls.

d. If there is information bias, is it towards or away from the null? Why?

2. In a cohort study with no loss to follow-up, disease status was misclassified as follows:
Study Population without Misclassification
I11
Healthy
Exposed
700
3,500
Unexposed
300
4,000
Study Population with Misclassification
I11
Healthy
Exposed
82:
3,100
Unexposed
200
3,500

3 . In a case - control study , exposure status was misclassified as follows
Study Population without Misclassification
Cases
Controls
Exposed
700
700
Unexposed
350
900
Study Population with Misclassification
Cases
Controls
Exposed
350
350
Unexposed
700
800

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