m Table 2. The multivariate adjusted odds ratios for postoperative infection. Model One SD Model 1 Model 2 Model 3 Model 4 Model 5 Odds Odds Odds
View the step-by-step solution to:

Question

In Model 1, which of the Base potential risk factors appears to have the greatest risk of infection associated

with it? Justify your choice using the information provided in Table 2.  

Which continuous predictor CRP or ADN level is better at explaining the infection status of the patient? Justify your answer.  


For continuous predictors the researchers' decided to use the same method for choosing an incremental value to use for calculating the OR, what was this method?  





table2.jpg

m
Table 2. The multivariate adjusted odds ratios for postoperative infection.
Model
One SD Model 1
Model 2
Model 3
Model 4
Model 5
Odds
Odds
Odds
Ratio
95%CI
Ratio
95%CI
Odds
Ratio
95%CI
Odds
Ratio
95%CI
Male Gender
Ratio
95%CI
0.92
0.36-2.32
0.89
0.35-2.31
45
0.47-4.46
1.30
Age (years)
0.41-4.14
11.60
1.16
0.91-1.47
1.51
0.45-4.9
1.21
0.94-1.56
1.21
0.88-1.66
1.32
BMI (kg/m?)
0.95-1.85
1.30
3.80
0.81
0.54-1.23
0.91-1.60
0.80
0.52-1.21
0.89
0.557-1.39
0.88
0.56-1.38
ASA1 (%)
0.91
1 (ref.)
0.58-141
1 ( ref. )
1 (ref.)
1 (ref.)
ASA2 (%)
1 (ref.)
3.01
0.98-9.21
2.89
0.90-9.30
3.52
0.75-16.41
3.45
0.72-16.55
3.40
ASA3 (%)
0.70-16.75
3.66
0.59-22.80
3.60
0.55-23.62
2.75
0.30-25.47
3.00
0.31-29.15
2.60
0.30-26.40
DM (%)
3.50
1.11-11.05
.00
1.20-13.28
5.28
1.35-20.69
5.56
1.37-22.66
5.86
1.42-24.30
Total operation
114.10
1.55
0.88-2.74
1.58
0.88-2.84
1.62
0.79-3.29
.76
0.84-3.68
1.71
time
0.81-3.50
Log (blood loss)
616.20
6.59
1.88-23.14"
6.18
1.69-22.66"
2.83
0.70-11.52
2.54
0.60-10.80
2.86
3.60-12.82
Surgical
2.20
0.79-6.11
2.40
0.82-7.00
2.74
0.77-9.76
3.32
0.88-12.50
3.21
0.90-12.24
procedure (%)
CRP (mg/al)
3.50
1.51
0.93-2.43
1.52
0.86-2.67
1.53
0.90-2.71
ADN ratio
0.20
14.90
4.62-48.00
15.73
4.64-53.37"
15.20
4.50-51.13
*p<0.05,
*#p<0.01.
Model 1: Basic potential risk factors [gender, patient age, BMI, log (blood loss), ASA, T2DM, and the surgical procedure]; Model 2: Basic factors plus CRP levels; Model 3:
Basic factors plus ADN ratio; Model 4: Basic factors plus preoperative ADN levels; Model 5: Basic factors plus CRP and preoperative ADN levels and ADN ratio. Blood loss
was included in the models as log (blood loss), which was normally distributed, whereas CRP levels were mostly normally distributed. The odds ratio for each continuous
variable was expressed for one standard deviation increase [11.61 for age; 3.82 for BMI; 616.17 for log (blood loss); 114.12 for time; 3.47 for CRP levels (POD 1); 5.09 for
preoperative ADN levels; and 0.21 for ADN ratio]. The odds ratio was calculated for one standard deviation decrease only for the ADN ratio. Cl: confidence interval.
doi:10.1371/journal.pone.0056129.t002
PLOS ONE | www.plosone.org
March 2013 | Volume 8 | Issue 3 | e56129

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