m

Table 2. The multivariate adjusted odds ratios for postoperative infection.

Model

One SD Model 1

Model 2

Model 3

Model 4

Model 5

Odds

Odds

Odds

Ratio

95%CI

Ratio

95%CI

Odds

Ratio

95%CI

Odds

Ratio

95%CI

Male Gender

Ratio

95%CI

0.92

0.36-2.32

0.89

0.35-2.31

45

0.47-4.46

1.30

Age (years)

0.41-4.14

11.60

1.16

0.91-1.47

1.51

0.45-4.9

1.21

0.94-1.56

1.21

0.88-1.66

1.32

BMI (kg/m?)

0.95-1.85

1.30

3.80

0.81

0.54-1.23

0.91-1.60

0.80

0.52-1.21

0.89

0.557-1.39

0.88

0.56-1.38

ASA1 (%)

0.91

1 (ref.)

0.58-141

1 ( ref. )

1 (ref.)

1 (ref.)

ASA2 (%)

1 (ref.)

3.01

0.98-9.21

2.89

0.90-9.30

3.52

0.75-16.41

3.45

0.72-16.55

3.40

ASA3 (%)

0.70-16.75

3.66

0.59-22.80

3.60

0.55-23.62

2.75

0.30-25.47

3.00

0.31-29.15

2.60

0.30-26.40

DM (%)

3.50

1.11-11.05

.00

1.20-13.28

5.28

1.35-20.69

5.56

1.37-22.66

5.86

1.42-24.30

Total operation

114.10

1.55

0.88-2.74

1.58

0.88-2.84

1.62

0.79-3.29

.76

0.84-3.68

1.71

time

0.81-3.50

Log (blood loss)

616.20

6.59

1.88-23.14"

6.18

1.69-22.66"

2.83

0.70-11.52

2.54

0.60-10.80

2.86

3.60-12.82

Surgical

2.20

0.79-6.11

2.40

0.82-7.00

2.74

0.77-9.76

3.32

0.88-12.50

3.21

0.90-12.24

procedure (%)

CRP (mg/al)

3.50

1.51

0.93-2.43

1.52

0.86-2.67

1.53

0.90-2.71

ADN ratio

0.20

14.90

4.62-48.00

15.73

4.64-53.37"

15.20

4.50-51.13

*p<0.05,

*#p<0.01.

Model 1: Basic potential risk factors [gender, patient age, BMI, log (blood loss), ASA, T2DM, and the surgical procedure]; Model 2: Basic factors plus CRP levels; Model 3:

Basic factors plus ADN ratio; Model 4: Basic factors plus preoperative ADN levels; Model 5: Basic factors plus CRP and preoperative ADN levels and ADN ratio. Blood loss

was included in the models as log (blood loss), which was normally distributed, whereas CRP levels were mostly normally distributed. The odds ratio for each continuous

variable was expressed for one standard deviation increase [11.61 for age; 3.82 for BMI; 616.17 for log (blood loss); 114.12 for time; 3.47 for CRP levels (POD 1); 5.09 for

preoperative ADN levels; and 0.21 for ADN ratio]. The odds ratio was calculated for one standard deviation decrease only for the ADN ratio. Cl: confidence interval.

doi:10.1371/journal.pone.0056129.t002

PLOS ONE | www.plosone.org

March 2013 | Volume 8 | Issue 3 | e56129