View the step-by-step solution to:

Microchimerism: a blessing in disguise?

DEAR Tutor,
I appreciate you can answer only three questiion at a time. but these are questions that have already be answered, but completely. I asked for the graph of the case and control sample, instead you sent me a notepad with variables and NOT in a TABLE. this is making things difficult for the both of us, because you are not adressing the problem. therefore I keep sending it back to you.. I have copied the variables in the notepad into a table and I need you to confirm if i have arranged it the way it should look. I could not copy the 7252700 JPG GRAPH you sent. so could you please copy and paste it on slide 12. The work is overdue for submission already. But I would rather submit a complete piece of work LATE. Than submit an INCOMPLETE PIECE OF WORK EARLY.

Microchimerism: a blessing in disguise? Cell transfer happens through the umbilical cord during gestation period in both ways. Some of the transferred cells survive in the host body, and proliferate. This is called Microchimerism . When fetal cells survive in mother’s body, it’s fetal microchimereism . Microchimerism has been shown to provide protective effect in Breast Cancer in a previous paper: Gadi VK, Malone KE, Guthrie KA, Porter PL, Nelson JL (2008) Case-Control Study of Fetal Microchimerism and Breast Cancer. PLoS ONE 3(3): e1706. doi:10.1371/journal.pone.0001706. Since this most probably to happen through some secondary immunological mechanism, and Breast Cancer susceptibility and surface antigens vary with genotype, we can do this study for a specific ethnic group, for example Asians. This study is of course practicable but will involve a lot of effort for data collection.
Background image of page 01
The scientific hypothesis The null hypothesis we have here is that level of fetal microchimerism (FMc) has no effect on being affected with Breast Cancer, i.e. FMc does not provide a protective role in Breast Cancer. When a woman bears a male child, some cells with XY- chromosome survive in FMc in the mother’s body. We can quantify the amount of FMc by amount of fetal cells, which is measured by the relative quantity of Y- chromosome specific marker in the sample, and will be measured by Quantitiative PCR .
Background image of page 02
Show entire document
Sign up to view the entire interaction

Top Answer

We need you to clarify your question for our tutors! Clarification request: Dear Student,... View the full answer

Sign up to view the full answer

Why Join Course Hero?

Course Hero has all the homework and study help you need to succeed! We’ve got course-specific notes, study guides, and practice tests along with expert tutors.


Educational Resources
  • -

    Study Documents

    Find the best study resources around, tagged to your specific courses. Share your own to gain free Course Hero access.

    Browse Documents
  • -

    Question & Answers

    Get one-on-one homework help from our expert tutors—available online 24/7. Ask your own questions or browse existing Q&A threads. Satisfaction guaranteed!

    Ask a Question
Ask a homework question - tutors are online