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Week 8: Data Interpretation and Confounding Exercise Table 1 below describes data from a prospective cohort study examining the association between...

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Week 8: Data Interpretation and Confounding Exercise Table 1 below describes data from a prospective cohort study examining the association between type of work schedule and the risk of prostate cancer in men. Table 1: Incidence of prostate cancer in 14,052 male workers according to type of work schedule Work schedule Daytime Fixed night Rotating shift No. of subjects with no diagnosis of prostate cancer at the time of enrollment in the study 11,269 982 1,801 No. of person-years of follow- up 89,179 8,272 14,523 No. of new prostate cancer cases 21 3 7 Express your answers as per 10,000 person-years of follow-up where appropriate. A. What is the incidence density of prostate cancer in all participants in the study? (2 points) B. What is the incidence density of prostate cancer in daytime workers? (2 points) C. What is the incidence density of prostate cancer in fixed night workers? (2 points) D. What is the incidence density of prostate cancer in rotating shift workers? (2 points) E. What is the ratio of the person-time incidence (or incidence density) of prostate cancer in fixed night shift to the person-time incidence of prostate cancer in Daytime workers? (2 points) F. What is the ratio of the person-time incidence of prostate cancer in rotating shift to the person-time incidence of prostate cancer in Daytime workers? (2 points) 1
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G. How do rates of prostate cancer among fixed night and rotating shift compare to the rate of prostate cancer in daytime shift? What would you conclude about the relationship between work schedule and risk or rate of prostate cancer? Why? (2 points) H. Assuming that all participants were followed up for a total of 8 years with complete follow-up, what would be the cumulative incidence (risk) of prostate cancer in daytime workers for the 8-year period? (2 points) 2
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